Publications

• 2026

• Shu L-J, Nicoli A, Yu F-Y, Thiry O O A, Deslandes-Hérold G, Luethi T, Di Pizio A, Ranf S (2026)

  The plant immune receptor LORE binds agonistic and antagonistic 3-hydroxy fatty acid ligands via a dynamic loop in its G-type lectin domain

  bioRxiv DOI: 10.64898/2026.06.08.730953 (preprint)

  

• Shu L-J, Schönberger L, Ziffermayer L, Yu F-Y, Deslandes-Hérold G, Schmid C, Gigl M, Schäffer M, Dawid C, Ranf S (2026)

  Diversification of ligand preference in conserved Brassicaceae LORE immune receptors matches proteobacterial 3-hydroxy fatty acid profiles

  bioRxiv DOI: 10.64898/2026.05.15.725355 (preprint)

  

• Gilliard G, Pršić J, Crowet J-M, Chemotti C, Ahmed J, Lorent J, Jolivet M-D, Egli S, Egée S, Bouyer G, Race G, van Buren L, Van Den Berghe A, Argüelles-Arias A, Mathelié-Guinlet M, Ibrahim H, Genva M, Fouillen L, Mirande-Bret C, Razin O, Vue B, Župunski M, Luzuriaga-Loaiza W P, Deboever E, Nasir M N, Lins L, Van Der Smissen P, Boubsi F, Eschrig S, Germain V, Höfte M, Zipfel C, Dufrêne Y F, Tyteca D, Koutsioubas A, Brocca P, Grossmann G, Ranf S, Dorey S, De Coninck B, Nürnberger T, Mongrand S, Gronnier J, Rondelli V, Deleu M, Ongena M (2026)

  Membrane remodelling mediates lipopeptide-induced immunity in Arabidopsis

  Nat Plants 12: 1034-1050

  

• Shu L-J, Yu F-Y, Ranf S (2026)

  Plant-Based Ligand-Depletion Binding Assay for Assessing Pattern Recognition Receptor-Ligand Interactions

  Methods Mol Biol 3012: 35-56

  

• 2025

• Duchateau S, Crouzet J, Cordelier S, Touchard M, Schellenberger R, Borrego C, Villaume S, Guise J-F, Esmaeel Q, Groleau M-C, Cloutier M, Gauthier C, Dhondt-Cordelier S, Mazeyrat-Gourbeyre F, Baillieul F, Ranf S, Déziel E, Aziz A, Dorey S (2025)

  Pantoea ananatis-triggered systemic resistance requires root sensing through the LORE receptor kinase in Arabidopsis

  bioRxiv DOI: 10.1101/2025.11.18.688997 (preprint)

  

• Li T, Meira F, Bolaños E J, Guel B, Padilla C, Mandadi K K, Thomson J G, Ranf S, Coaker G (2025)

  Introducing Pattern Recognition Receptors in Potato Confers Enhanced Resistance to Ralstonia Solanacearum but not a Vector Borne Pathogen

  Plant Biotechnol J DOI: 10.1111/pbi.70268

  

• 2024

• Eschrig S, Kahlon P S, Agius C, Holzer A, Hückelhoven R, Schwechheimer C, Ranf S (2024)

  Cross-family transfer of the Arabidopsis cell-surface immune receptor LORE to tomato confers sensing of 3-hydroxylated fatty acids and enhanced disease resistance

  Mol Plant Pathol DOI: 10.1111/mpp.70005

  

• Eschrig S, Schäffer M, Shu L-J, Illig T, Eibel S, Fernandez A, Ranf S (2024)

  LORE receptor homomerization is required for 3-hydroxydecanoic acid-induced immune signaling and determines the natural variation of immunosensitivity within the Arabidopsis genus

  New Phytol DOI: 10.1111/nph.19715

  

• 2023

• Shu L-J, Kahlon P S, Ranf S (2023)

  The power of patterns: new insights into pattern-triggered immunity

  New Phytol 240: 960-967

  

• Bauer K, Nayem S, Lehmann M, Wenig M, Shu L-J, Ranf S, Geigenberger P, Vlot A C (2023)

  β-D-XYLOSIDASE 4 modulates systemic immune signaling in Arabidopsis thaliana

  Front. Plant Sci. DOI: 10.3389/fpls.2022.1096800

  

• 2022

• Gerster T, Wröbel M, Hofstaedter C E, Schwudke D, Ernst R K, Ranf S, Gisch N (2022)

  Remodeling of Lipid A in Pseudomonas syringae pv. phaseolicola In Vitro

  Int J Mol Sci 23: 1996

  

• 2021

• Schellenberger R, Crouzet J, Nickzad A, Shu L-J, Kutschera A, Gerster T, Borie N, Dawid C, Cloutier M, Villaume S, Dhondt-Cordelier S, Hubert J, Cordelier S, Mazeyrat-Gourbeyre F, Schmid C, Ongena M, Renault J-H, Haudrechy A, Hofmann T, Baillieul F, Clément C, Zipfel C, Gauthier C, Déziel E, Ranf S, and Dorey S (2021)

  Bacterial rhamnolipids and their 3-hydroxyalkanoate precursors activate Arabidopsis innate immunity through two independent mechanisms

  Proc Natl Acad Sci U S A 118 (39) e2101366118

  

• Shu L-J, Schäffer M, Eschrig S, Ranf S (2021)

  Low cost, medium throughput depletion-binding assay for screening S-domain-receptor ligand interactions using in planta protein expression

  bioRxiv DOI: 10.1101/2021.06.16.448648 (preprint)

  

• Kutschera A, Schombel U, Schwudke D, Ranf S, and Gisch N (2021)

  Analysis of the Structure and Biosynthesis of the Lipopolysaccharide Core Oligosaccharide of Pseudomonas syringae pv. tomato DC3000

  Int J Mol Sci 22: 3250

  

• Coleman A D, Maroschek J, Raasch L, Takken F L W, Ranf S, Hückelhoven R (2021)

  The Arabidopsis leucine‐rich repeat receptor‐like kinase MIK2 is a crucial component of early immune responses to a fungal‐derived elicitor

  New Phytol 229: 3453-3466

  

• 2020

• Trempel F, Eschen‐Lippold L, Bauer N, Ranf S, Westphal L, Scheel D, Lee J (2020)

  A mutation in Asparagine‐Linked Glycosylation 12 (ALG12) leads to receptor misglycosylation and attenuated responses to multiple microbial elicitors

  FEBS Lett 594: 2440–2451

  

• 2019

• Kutschera A, Schombel U, Wröbel M, Gisch N and Ranf S (2019)

  Loss of wbpL disrupts O-polysaccharide synthesis and impairs virulence of plant-associated Pseudomonas strains

  Mol Plant Pathol 20: 1535-1549

  

• (2019)

  Kutschera A^*, Dawid C^*, Gisch N, Schmid C, Lars Raasch L, Tim Gerster T, Schäffer M, Smakowska-Luzan E, Belkhadir Y, Vlot A C, Chandler C E, Schellenberger R, Schwudke D, Ernst R K, Dorey S, Hückelhoven R, Hofmann T, Ranf S (2019) Bacterial medium-chain 3-hydroxy fatty acid metabolites trigger immunity in Arabidopsis plants. Science Vol. 364: 178-181

  Abstract   Full text  PDF
  ^*These authors contributed equally to this work.
   recommended

  

• (2019)

  Kutschera A, Ranf S (2019) The multifaceted functions of lipopolysaccharide in plant-bacteria interactions

  Biochimie 159: 93-98 (Review)

  

• 2018

• (2018)

  Ranf S (2018) Pattern Recognition Receptors – Versatile Genetic Tools for Engineering Broad-Spectrum Disease Resistance in Crops

  Agronomy (Special Issue Biotic and Abiotic Stress Responses in Crop Plants) (Perspective)

  

• 2017

• (2017)

  Kutschera A, Lamb JJ (2017) Cost-Effective Live Cell Density Determination of Liquid Cultured Microorganisms

  Curr Microbiol DOI 10.1007/s00284-017-1370-3

  

• (2017)

  Ranf S (2017) Sensing of molecular patterns through cell surface immune receptors

  Curr Opin Plant Biol 38: 68-77 (Review)

  

• (2017)

  Vaddepalli P, Fulton L, Wieland J, Wassmer K, Schaeffer M, Ranf S, Schneitz K (2017) The cell wall-localized atypical ß-1,3 glucanase ZERZAUST controls tissue morphogenesis in Arabidopsis thaliana

  Development doi: 10.1242/dev.152231

  

• 2016

• Ranf S, Scheel D, and Lee J (2016)

  Challenges in the identification of microbe-associated molecular patterns in plant and animal innate immunity: a case study with bacterial lipopolysaccharide

  Mol Plant Pathol 2016 Oct;17(8):1165-9. doi: 10.1111/mpp.12452 (Review)

  

• Ranf S (2016)

  Immune Sensing of Lipopolysaccharide in Plants and Animals: Same but Different

  PLoS Pathog 12: e1005596 (Review)

  

• Scheler B, Schnepf V, Galgenmüller C, Ranf S, and Hückelhoven R (2016)

  Barley disease susceptibility factor RACB acts in epidermal cell polarity and positioning of the nucleus

  J Exp Bot 10.1093/jxb/erw141

  

• Trempel F, Kajiura H, Ranf S, Grimmer J, Westphal L, Zipfel C, Scheel D, Fujiyama K, and Lee J (2016)

  Altered glycosylation of exported proteins, including surface immune receptors, compromises calcium and downstream signaling responses to microbe-associated molecular patterns in Arabidopsis thaliana

  BMC Plant Biol 16: 31

  

• Trempel F, Ranf S, Scheel D, and Lee J (2016)

  Quantitative Analysis of Microbe-Associated Molecular Pattern (MAMP)-Induced Ca(2+) Transients in Plants

  Methods Mol Biol 1398: 331-344

  

• 2015

• Ranf S, Gisch N, Schäffer M, Illig T, Westphal L, Knirel YA, Sánchez-Carballo PM, Zähringer U, Hückelhoven R, Lee J, and Scheel D (2015)

  A lectin S-domain receptor kinase mediates lipopolysaccharide sensing in Arabidopsis thaliana

  Nat Immunol 16: 426-433
  Commentary by Cyril Zipfel in Nature Immunology
  Research Highlight in Nature Plants

  

• 2014

• Ranf S, Eschen-Lippold L, Fröhlich K, Westphal L, Scheel D, and Lee J (2014)

  Microbe-associated molecular pattern-induced calcium signaling requires the receptor-like cytoplasmic kinases, PBL1 and BIK1

  BMC Plant Biol 14: 374

  

• Seybold H, Trempel F, Ranf S, Scheel D, Romeis T, and Lee J (2014)

  Ca²⁺ signalling in plant immune response: from pattern recognition receptors to Ca²⁺ decoding mechanisms

  New Phytol 204: 782-790 (Review)

  

• 2012

• Ranf S, Grimmer J, Pöschl Y, Pecher P, Chinchilla D, Scheel D, and Lee J (2012)

  Defense-related calcium signaling mutants uncovered via a quantitative high-throughput screen in Arabidopsis thaliana

  Mol Plant 5: 115-130

  

• 2011

• Ranf S, Eschen-Lippold L, Pecher P, Lee J, and Scheel D (2011)

  Interplay between calcium signalling and early signalling elements during defence responses to microbe- or damage-associated molecular patterns

  Plant J 68: 100-113

  

• 2009

• Vadassery J, Ranf S, Drzewiecki C, Mithöfer A, Mazars C, Scheel D, Lee J, and Oelmüller R (2009)

  A cell wall extract from the endophytic fungus Piriformospora indica promotes growth of Arabidopsis seedlings and induces intracellular calcium elevation in roots

  Plant J 59: 193-206

  

• 2008

• Ranf S, Wünnenberg P, Lee J, Becker D, Dunkel M, Hedrich R, Scheel D, and Dietrich P (2008)

  Loss of the vacuolar cation channel, AtTPC1, does not impair Ca²⁺ signals induced by abiotic and biotic stresses

  Plant J 53: 287-299

  

• 2007

• Gust AA, Biswas R, Lenz HD, Rauhut T, Ranf S, Kemmerling B, Götz F, Glawischnig E, Lee J, Felix G, and Nürnberger T (2007)

  Bacteria-derived Peptidoglycans Constitute Pathogen-associated Molecular Patterns Triggering Innate Immunity in Arabidopsis

  J Biol Chem 282: 32338-32348

  

• Kandoth PK, Ranf S, Pancholi SS, Jayanty S, Walla MD, Miller W, Howe GA, Lincoln DE, and Stratmann JW (2007)

  Tomato MAPKs LeMPK1, LeMPK2, and LeMPK3 function in the systemin-mediated defense response against herbivorous insects

  Proc Natl Acad Sci USA 104: 12205-12210

  

• 2002

• Niller HH, Salamon D, Uhlig J, Ranf S, Granz M, Schwarzmann F, Wolf H, and Minarovits J (2002)

  Nucleoprotein Structure of Immediate-Early Promoters Zp and Rp and of oriLyt of Latent Epstein-Barr Virus Genomes

  J Virol 76: 4113-4118

  

Talks and posters

• 2026

• CUSO Molecular Plant Sciences PhD retreat: Plant Membrane Signaling Schloss Münchenwiler, Münchenwiler, Switzerland · 25-26 June 2026

  • invited talk Stefanie Ranf

• Invited seminar, Julius-Kühn-Institut Braunschweig, Germany · January 2026

  • invited talk Stefanie Ranf

• 2025

• 13th Plant Peptide and Receptor Meeting John McIntyre Conference Centre, Edinburgh, United Kingdom · 8-10 September 2025

  • poster Stefanie RanfThe PRR LORE is highly expressed at microbial entry sites
  • poster Aimen SultanCLEAN-LORE - controlled activation of LORE kinase signaling using receptor chimera
  • poster Bruno SmetIn silico analysis of the LORE kinase domain
  • poster Fan-Yu YuThree residues of LORE are important for 3-hydroxy fatty acid binding

• 21st International Congress on Molecular Plant-Microbe Interactions Koelnmesse Confex, Cologne, Germany · 13-17 July 2025

  • poster Stefanie RanfThe PRR LORE is highly expressed at microbial entry sites
  • poster Aimen SultanCLEAN-LORE - controlled activation of LORE kinase signaling using receptor chimera
  • poster Fan-Yu YuInvestigation of LORE receptor binding specificity to medium chain 3-hydroxylated fatty acids
  • poster Bruno SmetSuccessful N-terminal tagging of the pattern recognition receptor LORE

• 1st International Symposium on Soil and Plant Health in a Changing Environment Campus Croix-Rouge, Université de Reims Champagne-Ardenne, Reims, France · 26-28 May 2025

  • talk Stefanie RanfThe cell-surface immune receptor LORE from Brassicaceae: from natural diversity to mechanistic insights and translation to crop protection

• 2024

• 12th Plant Peptides and Receptors Meeting Fletcher Hotel De Wageningsche Berg, Wageningen, Netherlands · September 2024

  • poster Fan-Yu YuStructural and computational investigation of LORE receptor binding specificity to medium chain 3-hydroxylated fatty acid
  • poster Aimen SultanUnveiling the molecular interplay between phosphosensors and calmodulins in regulating early LORE immune signaling in plants

• International Plant Proteostasis Conference 2024 Vienna, Austria · September 2024

  • poster Bruno SmetInvestigating the regulation of LORE signaling through E3 ligases and endocytosis

• Plant Science Student Conference 2024 Leibniz Institute of Plant Biochemistry, Halle (Saale), Germany · 20 June 2024

  • talk Stefanie RanfMultiple roles of lipopolysaccharide in plant-bacteria interactions: plant immune elicitor and bacterial virulence factor?

• Seminar series, University of Bern Bern, Switzerland · 22 April 2024

  • invited talk Stefanie RanfMultiple roles of lipopolysaccharide in plant-bacteria interactions: plant immune elicitor and bacterial virulence factor?

• 2023

• 11th Plant Peptides and Receptors Meeting École Normale Supérieure de Lyon, Lyon, France · October 2023

  • talk Lin-Jie ShuCapturing 3-hydroxy fatty acid: characterization of the immune receptor LORE in Brassicaceae
  • poster Stefanie RanfLORE mediated immunity in Brassicaceae: mechanistic insights from natural diversity
  • poster Bruno SmetDeveloping tools to study the regulation of the immune receptor LORE
  • poster Fan-Yu YuIdentify the potential role of LORE paralogs in the 3-OH-FA-triggered immune response of Arabidopsis
  • poster Priyanka RavirajRegulation of immune receptor kinase LORE by calcium sensor calmodulins

• 20th International Congress on Molecular Plant-Microbe Interactions Providence, Rhode Island, United States · 16-20 July 2023

  • talk Lin-Jie ShuCapturing 3-hydroxy fatty acid: characterization of the immune receptor LORE in Brassicaceae

• IPB Symposium 2023 Leibniz Institute of Plant Biochemistry, Halle (Saale), Germany · 8 May 2023

  • talk Stefanie RanfMultiple roles of LPS in plant-bacteria interactions: plant immune elicitor and bacterial virulence factor?

• LS2 Annual Meeting Zurich, Switzerland · February 2023

  • talk Stefanie RanfBacterial 3-hydroxy fatty acid metabolites activate LORE-mediated immunity in cruciferous plants

• 2022

• Seminar series, University of Zurich Zurich, Switzerland · 30 September 2022

  • invited talk Stefanie RanfMultiple roles of LPS in plant-bacteria interactions: plant immune elicitor and bacterial virulence factor?